Dmm023036 1171..1174
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چکیده
Model systems, including laboratory animals, microorganisms, and celland tissue-based systems, are central to the discovery and development of new and better drugs for the treatment of human disease. In this issue, Disease Models & Mechanisms launches a Special Collection that illustrates the contribution of model systems to drug discovery and optimisation across multiple disease areas. This collection includes reviews, Editorials, interviews with leading scientists with a foot in both academia and industry, and original research articles reporting new and important insights into disease therapeutics. This Editorial provides a summary of the collection’s current contents, highlighting the impact of multiple model systems in moving new discoveries from the laboratory bench to the patients’
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Anaphylaxis to mustard.
2. Reid, J.L., Dargie, J.H., Davies, D.S., Wing, L.M.H., Hamilton, C.A. & Dollery, C.T. Clonidine withdrawal in hypertension. Changes in blood-pressure and plasma and urinary catecholamines. Lancet 1977, i: 1171-1174. 3. Hansson, L., Hunyor, S.N., Julius, S. & Hoobler, S.W. Blood pressure crisis following withdrawal of clonidine with special reference to arterial and urinary catecholamine level...
متن کاملSingle and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers
BACKGROUND HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a promising antioxidant with therapeutic potential for hepatic fibrosis. The aim of this study was to investigate the tolerability and pharmacokinetics of HX-1171 in healthy volunteers. METHODS A randomized, single-blind, placebo-controlled, dose escalation study was conducted in 83 subjects. In the single ascending dose study, 20,...
متن کاملMosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut.
Lineage-specific microRNAs (miRNAs) may contribute to functions specific to hematophagous mosquitoes and, as such, have potential for contributing to the development of future mosquito control approaches. Here we report that the mosquito- and gut-specific miRNA, miR-1174, is required for proper sugar absorption, fluid excretion, blood intake, and, consequently, egg maturation and survival in fe...
متن کاملA note on domination in bipartite graphs
DOMINATING SET remains NP -complete even when instances are restricted to bipartite graphs, however, in this case VERTEX COVER is solvable in polynomial time. Consequences to VECTOR DOMINATING SET as a generalization of both are discussed.
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